Utah & Vanderbilt Collaboration

DDInteract

Drug-drug interaction decision support at the point of prescribing.

The Problem

Alert fatigue is undermining patient safety.

Polypharmacy is common in hospitalised patients. Existing drug-drug interaction (DDI) alerts fire so frequently, and with such poor clinical specificity, that clinicians routinely override them, even when the interaction is genuinely dangerous.

DDInteract takes a user-centred approach to redesigning how DDI information is presented, reducing noise, improving actionability, and making the right choice the easy choice.

Interaction Severity Breakdown

Severe / Contraindicated 8%
Moderate, monitor 34%
Minor / informational 58%

Most alerts are minor, but all fire with the same visual urgency. DDInteract addresses this.

Approach

Designed with and for prescribers.

Risk Stratification

Presenting DDI risk with clinical context, patient-specific factors, severity grading, and actionable guidance, so clinicians can make informed decisions quickly.

User-Centred Design

Co-designed with prescribers through iterative cycles of prototyping, usability testing, and contextual inquiry across participating sites.

Actionable Recommendations

Rather than just flagging an interaction, DDInteract provides concrete next steps: dose adjustment, monitoring parameters, or safer alternatives.

Collaborators

Multi-site collaboration.

University of Utah Health

University of Utah

Salt Lake City, UT

Vanderbilt Health

Vanderbilt University

Nashville, TN

CU

CU Anschutz

Aurora, CO (PI)